In situ gel system for ocular drug delivery is one of the novel approaches investigated thoroughly with a number of combinations of available polymeric materials 16. Formulation and evaluation of niosomal in situ gel ocular delivery system of brimonidine tartrate. Eaga chandra mohan, jagan mohan kandukuri, venkatesham allenki. It has antibacterial, analgesic, and antiinflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice.
Insitu forming polymeric formulations drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation insitu to form a gel, from which drug gets released in sustained and controlled manner. This study aims to formulate and evaluate the temperaturesensitive in situ gel of 0. Formulation development and evaluation of insitu nasal gel. Among the different montelukast sodium in situ gel formulations, the formulations f5 and f6 were selected as the best formulation on the basis of various evaluation parameters such as their clarity, gelation temperature, drug contents and in vitro diffusion studies. Formulation and evaluation of an in situ gelforming ophthalmic. Formulation and evaluation of nasal in situ gel for alzheimer. Present dosage form includes thermosensitive polymers and ph activated polymers for in situ gel formulation. The formulation of gel depends upon factors like temperature modulation, ph changes, presence of. Formulated in situ gel were stable at the selected temperature and humidity in storage for 3 month. It is extracted from the essential oil of various medicinal plants. Fs college of pharmacy vilad ghat, ahmednagar, maharashtra414001, india abstract. Formulation and evaluation of periodontal in situ gel. Sumit durgapal 1, mahendra rana 1, sayantan mukhopadhyay 2, amita joshi rana 1, laxmi goswami 3 and sumit. The intension behind the present work was formulation and evaluation of in situ gel of brimonidine tartrate.
Seetha devi department of pharmaceutics, hindu college of pharmacy, guntur, andhra pradesh, india abstract in situ gel drug delivery systems are in solution form before administration but once administered, undergo. Formulation and evaluation of gel loaded microsponges of diclofenac sodium for topical delivery. Finally, the concentration of fusidic acid in formulations was 2% ww. Full text development and evaluation of insitu nasal gel. Sathyavathi, a abdul hasansathali, r ilavarasan and t sangeetha. Formulation and evaluation of nasal in situ gel of phenylephrine hydrochloride mothukuri tejaswini and a.
Jun, 2014 the present study was aimed to formulate and evaluate in situ thermoreversible intranasal gel of an antimigraine drug rizatriptan benzoate. Mar 22, 2017 the prepared gel was subjected for rheological study, in vitro gelation, drug release study, antimicrobial study by disk diffusion method and others. The microsponges formulations were prepared by quasiemulsion solvent. Hence, from above it was concluded that formulation, in situ gel formulation hppgg7 was containing sodium alginate 1.
Harish, mohammed gulzar a, prabhu prabhakara,amitkumarsingh, and e. Formulation, invitro curcumin insitu gel for treatment of. Formulation and evaluation of clindamycin hcl in situ gel for. Development and evaluation of insitu nasal gel formulations. Development and characterization of insitu gel for ophthalmic. Formulation and evaluation of insitu nasal gel of montelukast sodium for the effective treatment of asthma html full text. Temperature sensitive in situ gels were successfully developed by the cold technique using poloxamer 188, poloxamer 407, poloxamer 338. The current study was designed to develop a topical gel formulation. International journal of drug research and technology, s. Pshibd 699 pelagia research library formulation and evaluation of insitu gel of bromhexine hydrochloride for nasal delivery m. Formulation and evaluation of periodontal in situ gel article pdf available in international journal of pharmaceutical investigation 31. Preliminary study was carried out to optimize different types and concentration of polymers such as poloxamer 188. To increase its aqueous solubility, it was incorporated as an inclusion complex in a 1.
Brimonidine tartrate is an antiglaucomic agent which shows rapid precorneal exclusion and reduced ocular bioavailability when given in form of conventional ophthalmic. All the formulations were subjected to various evaluation parameters. Hec formulation was developed and in vitro transdermal penetration of this formulation was compared with that commercial vurdon gel 1% help. Kanwal1, ahmad 1nawaz1, amna shah1 and ghulam murtaza. Formulation and evaluation of thermoreversible in situ ocular gel of clonidine hydrochloride for glaucoma katpale avinash t and shinde ajay svpms college of pharmacy, malegaon bk, baramati, pune, maharashtra415, india abstract the aim of this research is undertaken to formulate thermo sensitive drug delivery system of clonidine. Pdf formulation and evaluation of periodontal in situ gel. Formulation and in vitro evaluation of in situ gels. The phase transition temperature was determined with visual method. Formulation and in vitro evaluation of carbopol 934based modified clotrimazole gel for topical application muhammad ubaid1, sadaf ilyas1, sadullah mir2, abida k. Drug content 2 it is determined by taking 1ml of the formulation and diluting it to 100ml with distilled water. Formulation and evaluation of thermosensitive in situ gel of brimonidine tartrate akash patil, amol tagalpallewar, ganesh rasve, arvind bendre, priyanka khapekar sinhgad institute of pharmacy, narhe, pune 411 041, maharastra, india abstract the intension behind the present work was formulation and evaluation of in situ gel of brimonidine. Development and evaluation insitu gel formulation of. Chaturvedi college of pharmacy, nagpur440 010, maharashtra, india. Formulation, invitro curcumin insitu gel for treatment.
Ophthalmic drug delivery is one of the most interesting. The purpose of this research was to prepare and evaluate the potential use of in situ gel formulations for dermal delivery of fusidic acid for burn wound treatment. Sodium alginate, a novel ophthalmic gelforming mucoadhesive polymer, which gets converted to gel in the presence of divalentcations calcium ion present in the lachrymal fluid, was used as the gelling agent. Formulation and evaluation of floating in situ gelling. Brimonidine tartrate, niosomes, thin film hydration, insitu gels, glaucoma. Formulation and evaluation of ph induced insitu nasal gel. All formulations were found to be transparent and clear.
Appropriate amount of poloxamer 407 was weighed in a 250 ml beaker, containing weighed amount of cold distilled water double distilled water containing. Formulation and evaluation of topical gel authorstream. After administration of in situ nasal gel formulation are sol form converts to gel form 4. In vivo, the 20% ffc in situ forming gel provided prolonged drug release time within the therapeutic range for about 100 h, with stable plasma levels and elimination half. Abdallah1 1department of pharmaceutics, faculty of pharmacy, alexandria university, alexandria, egypt and 2department of pharmaceutics, faculty of. The central composite design was used to optimize the effect of poloxamer. Preparation and evaluation of novel in situ gels containing. It increases the precorneal residence time and better bioavailability of drug can be achieved by formulating in situ gel. Formulation and evaluation of floating in situ gelling system. Formulation and evaluation of nasal in situ gel for. Formulation development and evaluation of insitu nasal. Formulation was developed to reduce the mucociliary clearance by using mucoadhesive polymer in gel, thereby increasing the contact time with nasal mucosa and hence improving the absorption of drug. Preparation and in vitro evaluation of an antibacterial in.
The main objective of present study is to formulate and evaluate methyl cellulose based in situ periodontal gel of atorvastatin. Pdf formulation and evaluation of in situ ophthalmic gels. The prepared gel was subjected for rheological study, in vitro gelation, drug release study, antimicrobial study by disk diffusion method and others. The objective of the present study was to formulate and evaluate a gastro retentive in situ gelling system of ciprofloxacin hcl using hpmc k100m, sodium alginate gelling polymer, calcium chloride and calcium carbonate as a cross linking agent for. The present investigation deals with development and evaluation of combination of bioresponsive polymers for the formulation of vaginal gel of clindamycin. Formulation and evaluation of ph induced 177 formulation and evaluation of ph induced insitu nasal gel of salbutamol sulphate tanaji nandgude1, rahul thube2, nitin jaiswal2, pradip deshmukh1, vivek chatap1, nitin hire2 1b. Cefuroxime axetil as in situ gel forming drug delivery system for oral delivery using. Formulation and in vitro evaluation of carbopol 934based.
For in situ gel formulation containing curcumin dissolved in ethanol, formulation was left on stirrer over night to allow ethanol evaporation before storage in refrigerator. Formulation and evaluation of controlled release gastro. Formulation and evaluation of sustained release sumatriptan mucoadhesive intranasal in situ gel article pdf available december 2019 with 75 reads how we measure reads. In vitro and in vivo evaluation of an in situ forming gel. The present study was aimed to formulate and evaluate in situ thermoreversible intranasal gel of an antimigraine drug rizatriptan benzoate. Subrahmanyam department of pharmaceutics, ngsm institute of pharmaceutical sciences, paneer, deralakatte, mangalore574 160, karnataka, india. Formulation and evaluation of thermoreversible, mucoadhesive. Formulation and evaluation of stomach specific insitu gel. The factors regulating of the in situ nasal gel formation process include microenvironmental temperature, changes in ph, presence of ions, ultraviolet irradiation and polymers 5. The prepared in situ gel formulations were evaluated for clarity, ph measurement, gelling capacity, drug content estimation, rheological study, in vitro diffusion study.
Formulation and evaluation of an in situ gel forming ophthalmic formulation of moxifloxacin hydrochloride. The poloxamer 407 and carbopol 934 were used as thermoreversible and mucoadhesive polymers respectively. Approaches ofin situ gel drug delivery there are four broadly defined mechanisms used for triggering thein situ gel formation of biomaterials. The in situ gel was prepared by using different concentration of methyl cellulose and gel was. Pshibd 699 pelagia research library formulation and evaluation of in situ gel of bromhexine hydrochloride for nasal delivery m. Formulation and evaluation of clindamycin hcl in situ gel.
The present work describes the formulation and evaluation of in situ gel forming ophthalmic formulation containing ciprofloxacin hydrochloride. In situ nasal gel of domperidone was prepared by using cold technique. Formulation development and evaluation of insitu ophthalmic gel of brimonidine tartarate vazir ashfaq ahmed 1, divakar goli 2 m. The aim of the present investigation is to prepare and evaluate in situ gelforming ophthalmic drug delivery system of moxifloxacin hydrochloride. Sodium alginate and guar gum were used as a polymer and caco 3 was used as a crosslinking agent. Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional chinese and indian medicine.
Pharmacokinetic evaluation showed that the prepared insitu gel of sutloaded nanotransferosomes gave enhanced bioavailability, 4. Preparation and evaluation of insitugels for ocular drug delivery. Preparation of ph triggered in situ gels of niosomes. Preparation and in vitro evaluation of an antibacterial. Formulation and evaluation of in situ gels containing clotrimazole for oral candidiasis n. Development and evaluation insitu gel formulation of clindamycin hcl for vaginal application jayshree b taksande, vyankatesh s bhoyar, rashmi v trivedi, milind j umekar. The present study was aimed to develop and optimize in situ gel for the treatment of periodontal disease. The ph of in situ gel formulation should be such that the formulation was be stable at that ph and at the same time, there would be no irritation to the patient upon administration of the formulation. Feb 28, 2017 formulation and evaluation of ph induced in situ nasal gel for brain targeting of levodopa. Indian journal of natural products and resources vol. Formulation and evaluation of thermosensitive in situ gel. The aim of the present study was to formulate and optimize norfloxacin in situ gels for the treatment of conjunctivitis. Pdf formulation and evaluation of in situ gels containing. Full text development and evaluation of insitu nasal.
Formulation and evaluation of in situ gels containing. The prepared dosage regimens provided ease in administration along. Formulation and evaluation of ph induced177 formulation and evaluation of ph induced insitu nasal gel of salbutamol sulphate tanaji nandgude1, rahul thube2, nitin jaiswal2, pradip deshmukh1, vivek chatap1, nitin hire2 1b. Formulation and evaluation of thermosensitive in situ gel of. These formulations remain in solution state before administration and transforms to gel after administration in to vaginal cavity. In this type of drug delivery system, the preparation is in a solution form before administration in body, but it converts into a gel form after administration shah and patel, 2010. Subrahmanyam ngsm institute of pharmaceutical sciences, paneer, deralakatte post, mangalore574 160, india harish, et al in situ gels of clotrimazole for oral candidiasis. Fabrication and physicochemical evaluation of insitu gel. Niosomal formulation showing maximum entrapment efficiency and in vitrorelease profile was selected for the preparation of in situ gel the in situ gelling systems of linezolid niosomes were prepared utilizing the phase transition properties of hydroxy propyl methyl cellulose k4m and carbopol 971p in different ratios. Formulation and in vitro evaluation of in situ gels containing secnidazole for vaginitis r. Pdf formulation and evaluation of in situ ophthalmic. The p resent work describes the formulation and evaluation of an ophthalmic delivery system of an a ntiinflammatory drug diclofenac sodium, based on the concept of ph triggered in situ gelati on by using sodium alginate, in vitro release studies indicated among the all formulations f1 sho ws better drug release when contacted with stf solution. Formulation and evaluation of floating sustained release in. Based on the evaluation in vivo evaluation it was concluded that gel formulation containing polymer 2% hpmc and permeation enhancer as 2% lemon grass oil showed better topical activity compare to that of the others formulations containing different polymers and permeation enhancers vivek kr and satish k prepared and characterized the gel.
Pdf formulation and evaluation of sustained release. Pdf gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile. Formulation and evaluation of ph induced insitu nasal gel of. Pharmacokinetic evaluation showed that the prepared in situ gel of sutloaded nanotransferosomes gave enhanced bioavailability, 4. Based on the evaluation invivo evaluation it was concluded that gel formulation containing polymer 2% hpmc and permeation enhancer as 2% lemon grass oil showed better topical activity compare to that of the others formulations containing different polymers and permeation enhancers vivek kr and satish k prepared and characterized the gel. Based on enhancing the bioavailability and sustaining the drug release, it can be concluded that the insitu gel of sutloaded nanotransferosomes were. The present investigation deals with the formulation and evaluation of floating in situ gel based gastroretentive drug delivery system of diltiazem hcl. In situ forming polymeric formulations drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in situ to form a gel. Based on enhancing the bioavailability and sustaining the drug release, it can be concluded that the in situ gel of sutloaded nanotransferosomes were.
The gel formulation was designed by using methanolic extract of leaves of c alata and c tora and aerial part of c. The formulation of gel depends upon factors like temperature modulation, ph changes, presence of ions and ultraviolet irradiation. Formulation and evaluation of floating sustained release in situ gel as carrier for stomach specific drug delivery of alfuzosin, international journal of advance research, ideas and innovations in technology, apa abhijeet p. In the present study, we proposed an in situ gel system composed of chitosan. General appearance 2 the general appearance of the formulation was observed which included colour and clarity of solution. Preparation and evaluation of qbd based fusidic acid. In situ is a latin word which means in its original place or in position. Formulation, invitro characterization and clinical evaluation of curcumin insitu gel for treatment of periodontitis maha m. Thus in the present study an attempt was made to prepare a formulation of. Formulation and evaluation of floating sustained release.
Topical antiinflammatory activity of gel was also evaluated. International journal of life science and pharma research 2012. From the literature, the formulation with hec gel base exhibited better properties for topical delivery of drugs when compared with the other formulations 3, 4. In which in situ phase transition occurs on the surface of the cornea. The present investigation deals with the formulation and evaluation of sodium alginate and pectin based in situ gel of losartan potassium. After administration of insitu nasal gel formulation are sol form converts to gel form 4. A weighed amount of poloxamer 407 and poloxamer 188 1520% wv was slowly added to 15 ml water at c in a beaker with continuous stirring using a magnetic stirrer at a speed of 500 rpm for 2 hrs. Development and evaluation of stability of a gel formulation. Dec 18, 2019 this study aims to formulate and evaluate the temperaturesensitive in situ gel of 0. In situ gel drug delivery system, a liquid formulation. In vitro evaluation of curcumin in situ gel gelation temperature the gelation temperature was determined using the testtubeinverting method. Formulation development and evaluation of a gastroretentive in situ. The ph of in situ gel solution was found to be around 6. In situ gel formulation which combines advantages of both gels and solution so that an accurate dose can be administered with ease.